Complexities of vitamin D metabolism still increasing

Vitamin D metabolism. Recent advances.

The increasing complexities of professionalism.

Organized medicine's modern-day professionalism movement has reached the quarter-century mark. In this article, the authors travel to an earlier time to examine the concept of profession within the work of Abraham Flexner. Although Flexner used the concept sparingly, it is clear that much of his writing on reforming medical education is grounded in his views on physicians as professionals and m...

Vitamin D Metabolism and Physiology

Background. Vitamin D insufficiency may lead to various health problems. By encouraging sun protection to prevent skin cancer, physicians may be limiting a major source of vitamin D for many individuals. Methods. We did a literature review on issues related to vitamin D inadequacy, particularly those relevant to various racial/ethnic groups. Results. Vitamin D is an important hormone with many ...

Vitamin D and Phospholipid Metabolism.

Although it has been known for many years that the primary physiological action of vitamin D is to improve calcium absorption from the small intestine (1,2), studies on calcium metabolism alone have thus far failed to elucidate the biochemical mechanism of action of vitamin D. Ry using everted intestinal sacs, Schacht,er and Rosen (3) have shown that vitamin D increases the transport of *%a aga...

Cytochrome P450-mediated metabolism of vitamin D.

The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review series. This review updates our current knowledge of the specific anabolic cy...